[GenABEL-dev] abstract for UseR! 2013

[Yurii Aulchenko]

Dear All,

Please find below an abstract I am going to send for the UseR! 2013
meeting.

Comments and suggestions are welcome! - the deadline is March 31

Yurii

\title{The GenABEL suite for genome-wide association analyses}

\begin{center}
  {\bf Yurii S Aulchenko$^{1,2,3,^\star}$, on behalf of the GenABEL project}
\end{center}

\keywords genome-wide association scans, SNP, complex traits,
statistical genomics

\vskip 0.8cm

Genome-wide association (GWA) analysis is a widely recognized
technique for identification of genomic regions
(loci) in which changes in DNA sequence lead to changes in complex
phenotype. In GWA scans, genomes of thousands of individuals are
assessed by use of single nucleotide polymorphisms (SNP) arrays or
whole-genome resequencing to gather information on hundreds of
thousands to millions of genetic variants. The trait values of
genotyped individuals are then tested for association with this
genetic variation. During last eight years, hundreds of loci for dozens of
human common disease and other complex traits were identified using
GWA scans.

The \pkg{GenABEL} project aims to provide a free framework for
collaborative, robust, transparent, open-source based development of
statistical genomics methodology.
In the framework of this project we have developed a suite of
packages facilitating different semi-independent types of GWA analyses.
The suite currently includes nine packages, of which seven are \proglang{R}
libraries, such as the
\pkg{GenABEL} for generic GWA quality control and analyzes, \pkg{MetABEL}
for meta-analysis,
\pkg{DatABEL} for large data sets management, \pkg{VariABEL} for
identification of potentially interacting variants, and others. The packages
are distributed under GPL or LGPL and are available at the
\pkg{GenABEL} project home page, \url{http://www.genabel.org}.
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