[GenABEL-dev] Robust Standard Errors for Cox Proportional Hazard Regression

[Alisa Manning]

Hello--
In the past, I've been involved in code contributions to ProbABEL
(extracting covariance between regression estimates for snp and snp*E for
interaction tests).

I've set aside some time this summer to work on implementing a weighted Cox
regression model in ProbABEL -- the only change that's required in the code
is to implement robust standard error estimation in the cox proportional
hazard functionality.

(Aside: I see that this is a feature request)

I noticed that the Cox regression model is under active development in
ProbABEL version 0.2.0.  The purpose of this email is to check in with the
group regarding my plan:

1) check out some latest developers version of the code
2) play around with the coxph code (if it isn't fixed)
3) evaluate and test in a statistical fashion (I am a biostatistician after
all!)
4) implement robust standard error estimation
5) submit patch for review

Comments and ideas are welcome.

Thanks!
Alisa

-- 

Alisa Knodle Manning, Ph.D.
Postdoctoral Research Fellow
Broad Institute
617-714-7662
amanning at broadinstitute.org
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