[GenABEL-dev] faster polygenic
Yurii Aulchenko
yurii.aulchenko at gmail.com
Thu Feb 17 13:05:35 CET 2011
> I think the residuals from the mixed model is the most interesting stuff
> that will be passed into the next GWAS in GenABEL.
>
>
an object returned by polygenic contains
h2an: A list supplied by the ‘nlm’ minimisation routine. Of
particular interest are elements "estimate" containing
parameter maximal likelihood estimates (MLEs) (order: mean,
betas for covariates, heritability, (polygenic + residual
variance)). The value of twice negative maximum
log-likelihood is returned as h2an\$minimum.
residualY: Residuals from analysis, based on covariate effects only;
NOTE: these are NOT grammar "environmental residuals"!
esth2: Estimate (or fixed value) of heritability
pgresidualY: Environmental residuals from analysis, based on covariate
effects and predicted breeding value.
InvSigma: Inverse of the variance-covariance matrix, computed at the
MLEs - these are used in ‘mmscore’ and ‘grammar’ functions.
call: The details of call
InvSigma, residualY and pgresidualY are used in other analyses (e.g. mmscore
and grammar)
anyways, given estimates and kin-matrix are there, it is not great deal to
compute these values
Yurii
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