[GenABEL-dev] Journal Club on Statistical Genomics

Yurii Aulchenko yurii.aulchenko at gmail.com
Fri Apr 1 19:17:28 CEST 2011


Ok, I see your point. I would suggest we take an 'evolutionary'
approach. Let me elaborate a bit on that.

When we started GenABEL-user forum, we discussed at lengths if we
should introduce a number of forums -- like GenABEL, ProbABEL, DatABEL
... but eventually we understood the power of the phpBB which allows
to shuffle the topics (and posts) between forums (Lennart or anyone
who is familiar with phpBB, please correct me if I am wrong).

So we decided to make a single forum, and see how it goes. If many
topics would start falling into distinctively different categories, we
could introduce a new forum and move the topics to that forum -- later
on. Probably, soon we may think of making 'GenABEL', 'ProbABEL' and
'Misc'.

I would think the same may work for the methodology forum. At first,
introduce single forum, and then see how it goes. I actually can
imagine that we may be willing to move few topics (or posts) from
GenABEL-user to the methodology discussion :)

best wishes,
Yurii

On Fri, Apr 1, 2011 at 11:04 AM, Maria G <mgmaria at yandex.ru> wrote:
> Hi dear all :)
>
>> Would you have a clear-cut question of type (3)
>
>
> In the section - Methodological nuances: «How to… ?» - I would discuss mostly questions of "how does the method work and why in a specific situations this one is better than the other".
>
> A good actual example we have right now on our GenABEL forum:
>
> http://forum.genabel.org/viewtopic.php?f=6&t=217&p=587#p587
>
> where the question has arisen:
>
> "If there are different methods of obtaining p-values from linear regression for association analysis and which one should is better to use?"
>
> And it's obvious that, might be, we just need a little bit more theoretical information to answer it and to find the differences between Plink and R-based GeanABEL (which is confusing for a lot of people! ;) ..)
>
> My personal feeling as a user of GenABEL is, that I want to understand exactly what's going on with my data, but not just to push the correct buttons in such a nice and powerfull tool  ;)
>
> My best wishes to all of yours :)
>
> Mascha


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