[Gsdesign-commits] r359 - pkg/gsDesign/man

[noreply at r-forge.r-project.org]

Author: keaven
Date: 2013-09-11 04:10:05 +0200 (Wed, 11 Sep 2013)
New Revision: 359

Modified:
   pkg/gsDesign/man/gsBoundSummary.Rd
Log:
Correction to default prior variance in gsBoundSummary documentation.

Modified: pkg/gsDesign/man/gsBoundSummary.Rd
===================================================================
--- pkg/gsDesign/man/gsBoundSummary.Rd	2013-09-11 02:05:20 UTC (rev 358)
+++ pkg/gsDesign/man/gsBoundSummary.Rd	2013-09-11 02:10:05 UTC (rev 359)
@@ -51,7 +51,7 @@
   \item{ddigits}{Number of digits past the decimal to be printed for the natural parameter delta.}
   \item{tdigits}{Number of digits past the decimal point to be shown for estimated timing of each analysis.}
   \item{timename}{Text string indicating time unit.}
-  \item{prior}{A prior distribution for the standardized effect size. Must be of the format produced by \code{normalGrid()}, but can reflect an arbitrary prior distribution. The default reflects a normal prior centered half-way between the null and alternate hypothesis with the variance being equivalent to the treatment effect estimate if 10 percent of the sample size for a fixed design were sampled. The prior is intended to be relatively uninformative. This input will only be applied if \code{POS=TRUE} is input.}
+  \item{prior}{A prior distribution for the standardized effect size. Must be of the format produced by \code{normalGrid()}, but can reflect an arbitrary prior distribution. The default reflects a normal prior centered half-way between the null and alternate hypothesis with the variance being equivalent to the treatment effect estimate if 1 percent of the sample size for a fixed design were sampled. The prior is intended to be relatively uninformative. This input will only be applied if \code{POS=TRUE} is input.}
   \item{ratio}{Sample size ratio assumed for experimental to control treatment group sample sizes. This only matters when \code{x} for a binomial or time-to-event endpoint where \code{gsRR} or \code{gsHR} are used for approximating the treatment effect if a test statistic falls on a study bound.}
   \item{exclude}{A list of test statistics to be excluded from design boundary summary produced; see details or examples for a list of all possible output values. A value of \code{NULL} produces all available summaries.}
   \item{POS}{This is an indicator of whether or not probability of success (POS) should be estimated at baseline or at each interim based on the prior distribution input in \code{prior}. The prior probability of success before the trial starts is the power of the study averaged over the prior distribution for the standardized effect size. The POS after an interim analysis assumes the interim test statistic is an unknown value between the futility and efficacy bounds. Based on this, a posterior distribution for the standardized parameter is computed and the conditional power of the trial is averaged over this posterior distribution.}