[GenABEL-dev] announcement for genabel.org

[Yurii Aulchenko]

Done!

http://www.genabel.org/news20131218

Please like on Facebook, re-tweet, like on scoop.it and LinkedIn...

http://www.scoop.it/t/statistical-omics/p/4012905113/2013/12/18/genomic-control-for-non-additive-models-genabel-org


On Wed, Dec 18, 2013 at 11:06 AM, L.C. Karssen <lennart at karssen.org> wrote:

> That's great news!
>
> Congratulations to Yakov and the others!
>
>
> Lennart.
>
> On 17-12-13 16:32, Yury Aulchenko wrote:
> > Dear All,
> >
> > please find below the news we'd like to add on the GenABEL.org late
> today / tomorrow in the morning
> >
> > best wishes,
> > Yurii
> >
> >
> > TC: Genomic control for non-additive models
> >
> > A manuscript on <a href="
> http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0081431">“Development
> and application of genomic control methods for genome-wide association
> studies using non-additive models”</a> was recently published on-line (PLOS
> ONE). The work reported in the manuscript extends the genomic control
> method to non-additive models; all methods are implemented in GenABEL.
> [click on 'READ MORE' below for complete story]
> >
> > With methods described, it is possible to correct the inflated statistic
> for non-additive models (such as recessive, dominant, over-dominant, and
> genotypic) in case a study population has genetic (sub)structure e.g. due
> to cryptic relatedness. Estimation of the correction coefficient is
> possible via the Variance Inflation Factor (VIF) and via polynomial of
> fixed degree (polynomial genomic control, PGC). The VIF estimation allows
> the corrections of 1df tests only, while PGC has more general application
> and also works for 2df genotypic test.
> >
> > All methods reported in the manuscript are available in the
> GenABEL-package (part of the GenABEL suite) as functions PGC, VIFGC,
> VIFGC_ovedom.
> >
> > We also take a chance to congratulate to Yakov Tsepilov - the first
> author of this study, and the GenABEL project contributor - on his
> first-as-first-author paper! Well done, and looking forward to see your
> next work!
> > _______________________________________________
> > genabel-devel mailing list
> > genabel-devel at lists.r-forge.r-project.org
> >
> https://lists.r-forge.r-project.org/cgi-bin/mailman/listinfo/genabel-devel
> >
>
> --
> *-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*
> L.C. Karssen
> Utrecht
> The Netherlands
>
> lennart at karssen.org
> http://blog.karssen.org
> GPG key ID: A88F554A
> -*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-
>
>
> _______________________________________________
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> genabel-devel at lists.r-forge.r-project.org
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>



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-----------------------------------------------------
Yurii S. Aulchenko

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