[GenABEL-dev] faster polygenic

[William Astle]

Hi

On 28/02/11 21:36, Yurii Aulchenko wrote:
> 2) still, FMM generates L which are>1 (1.014), and this is VERY
> significant. Old and hglm-based tend to be a bit on other side -- L<
> 1 (0.996 for old, 0.993 for hglm), and for hglm this is more
> pronounced


That's interesting, I guess the extra variance inflation is probably due 
to uncertainty in K which we don't model. I've wondered about extending 
the method to work with an uncertain K, I'm not sure how feasible 
statistically or computationally that would be.


bw

Will