[Genabel-commits] r1175 - pkg/GenABEL/man
noreply at r-forge.r-project.org
noreply at r-forge.r-project.org
Tue Mar 26 14:38:42 CET 2013
Author: lckarssen
Date: 2013-03-26 14:38:42 +0100 (Tue, 26 Mar 2013)
New Revision: 1175
Modified:
pkg/GenABEL/man/cocohet.Rd
Log:
Updated citation of the compound heterozygosity function (cocohet) in the documentation, because the paper has been published.
Modified: pkg/GenABEL/man/cocohet.Rd
===================================================================
--- pkg/GenABEL/man/cocohet.Rd 2013-03-24 23:52:58 UTC (rev 1174)
+++ pkg/GenABEL/man/cocohet.Rd 2013-03-26 13:38:42 UTC (rev 1175)
@@ -20,10 +20,16 @@
}
\details{
-The function is an inplementation of the method aimed to detect a gene-phenotype association caused by recessive and compound heterozygote genotype states of multiple
-rare variants at a particular gene locus. The paper 'Detecting rare recessive and compound heterozygote alleles in genome wide association and sequencing studies with red hair color as example'; Fan Liu, Maksim V. Struchalin, Kate van Duijn, Albert Hofman, Andre Uitterlinden2 Yurii S. Aulchenko2 and Manfred Kayser1.
-Submited to 'PLoS Genetics'.
+The function is an inplementation of the method aimed to detect a
+gene-phenotype association caused by recessive and compound heterozygote
+genotype states of multiple rare variants at a particular gene
+locus. This method is described in 'Detecting Low Frequent
+Loss-of-Function Alleles in Genome Wide Association Studies with Red
+Hair Color as Example'; Fan Liu, Maksim V. Struchalin, Kate van Duijn,
+Albert Hofman, André G. Uitterlinden, Yurii S. Aulchenko, and Manfred
+Kayser. PLoS ONE 6(11): e28145. doi:10.1371/journal.pone.0028145
+
The three tests are implemented: Pearson's chi-square test, Pearson's chi-square test with Yates correction, Fisher exact test.
In case when the input parameter min_expected_cut_off is <0 the choosen in the input parameter "test" test is performed. If min_expected_cut_off >= 0
then always Pearson's chi-square test is
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