[datatable-help] random factors in rma.mv (metafor)

[liso]

Hi,

I have a question regarding the use of rma.mv (metafor) in a multivariate
meta-analysis.
In particular, I have outcomes that vary not only between trials but also
between subjects. In other words, there are outcomes that have been measured
twice in one subject using different methods (mRNA, protein). This is true
for only a few studies, while others only report one method.
Hereby, I would like to deal with it?
So far, I have one random variable 'trial'.

Please find attached the code and a test dataset.
https://www.dropbox.com/s/gcn7e7e89g5nfr9/test.xlsx?dl=0

Thank you very much in advance.
Lisa

> rm(list = ls())
> library(metafor)
> library(readxl)
> dat1 <-
> read_excel("Documents/00_Data/12_MetaAnalysis/Data/test.xlsx",sheet =
> "BD_sorted")
>
>
> yi <- dat1$SMD
> V <- dat1$Variance
> W<-dat1$NoPatients
> res <- rma.mv(yi, V, W,mods = ~ Gen - 1, random =~ Gen | trial,
> struct="UN", data=dat1)
> res

Multivariate Meta-Analysis Model (k = 53; method: REML)

Variance Components:

outer factor: trial (nlvls = 11)
inner factor: Gen   (nlvls = 4)

            estim    sqrt  k.lvl  fixed   level
tau^2.1    0.2331  0.4828      5     no  NDUFA1
tau^2.2    0.0009  0.0303     10     no  NDUFS1
tau^2.3    0.0147  0.1212     17     no  NDUFV1
tau^2.4    0.0595  0.2440     21     no  NDUFV2

        rho.NDUFA  rho.NDUFS  rho.NDUFV1  rho.NDUFV2    NDUFA  NDUFS  NDUFV1 
NDUFV2
NDUFA1          1     0.5679      0.9493      0.9989        -     no      no     
no
NDUFS1     0.5679          1      0.2804      0.6060        1      -      no     
no
NDUFV1     0.9493     0.2804           1      0.9335        1      4       -     
no
NDUFV2     0.9989     0.6060      0.9335           1        2      4       5      
-

Test for Residual Heterogeneity:
QE(df = 49) = 119.9290, p-val < .0001

Test of Moderators (coefficient(s) 1:4):
QM(df = 4) = 11.8456, p-val = 0.0185

Model Results:

           estimate      se     zval    pval    ci.lb    ci.ub    
GenNDUFA1    0.4482  0.3377   1.3272  0.1845  -0.2137   1.1100    
GenNDUFS1   -0.1999  0.0641  -3.1211  0.0018  -0.3255  -0.0744  **
GenNDUFV1    0.0145  0.0779   0.1857  0.8527  -0.1382   0.1671    
GenNDUFV2   -0.0109  0.1272  -0.0854  0.9319  -0.2601   0.2383    

---
Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1 



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