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<body class='hmmessage'><div dir='ltr'><p class="MsoNormal" style="line-height: 16.35pt; background-position: initial initial; background-repeat: initial initial;"><span style="font-size:11.5pt;font-family:"Courier New";
color:#444444;mso-fareast-language:NO-BOK">Dear Dustin and Kosuke,<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"> </span></p>
<p class="MsoNormal"><span lang="EN-US">Is it
possible to estimate the direct and indirect effects when there is an
interaction between exposures (X1, X2), regressed on outcome Y? Since X2 is
also a mediator-outcome confounder between the mediation model X1>M>Y, and
X1 is also a mediator-outcome confounder between the mediation model
X2>M>Y, it is important to include them in the model as covariates, but
than what about the interaction between them? Note: all variables, X1, X2, M,
and Y are binary.<o:p></o:p></span></p>
<p class="MsoNormal"><br></p><p class="MsoNormal">I would highly appreciate any tips...</p><p class="MsoNormal"><br></p><p class="MsoNormal"><br></p>
<p class="MsoNormal"><span lang="EN-US">Thankfully,<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">Mashhood<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">Institute
of Community Medicine,<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">University
of Tromsų,<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">Norway.<o:p></o:p></span></p> </div></body>
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